The epIgG project, is a large cross-disciplinary collaboration of five labs from Sweden and Switzerland that is funded by the Knut & Alice Wallenberg Foundation. The overall epIgG project aims to explain the absolute link between IgG antibody epitope and their function at the protein-protein interface of host-bacteria interactions.
The project aims to develop new integrin biosensors, building upon the principle shown in our paper “Coordinated integrin activation by actin-dependent force during T-cell migration” in Nature Communications.
The sysmic project focuses on cell migration, a complex cellular process highly relevant to cancer. It is a SSF-funded grant within their Systems Biology program, led by Staffan Strömblad at Karolinska with the Nordenfelt Lab as one of the main participants. https://sysmic.ki.se/
We will further develop and apply a systems microscopy strategy by combining recently developed quantitative imaging and statistical modeling with a number of new developing imaging tools and, in a novel manner, with emerging cellular omics. All tailored to systematically unravel cellular and molecular dynamics of cell migration.
molecular basis for phagocytosis
The project aims to quantitatively determine the molecular requirements for Fc-mediated and CR-mediated phagocytosis.
bacterial invasion of human cells
The project aims to find common pathways used by multiple bacterial pathogens to invade human cells. The precise timing and molecular stoichometry will be studied.
antibody binding model
The project aims to establish a biophysical model for the binding of IgG antibodies to bacterial surfaces. This is a development of our paper “Antibody orientation at bacterial surfaces is related to invasive infection” in Journal of Experimental Medicine.
quantification of neutrophil extracellular traps
The project aims to develop software for automatic quantification of NETs.